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Mesylation of 5 (MsCl/CH 3 OH-Et 3 N-CH 2 Cl 2 /0 C), followed by lithium chloride treatment in DMF and hydrolysis (NaOCH 3 /CH 3 OH-CH 2 Cl 2 /room temperature) give the chloride 6 at a 95% overall yield
The monitoring frequency is adjusted according to the grade of dysplasia, with ACG guidelines indicating that BE patients without dysplasia may be monitored every 35 years, whereas patients with LGIN require more frequent monitoring (initially every 612 months, then annually)
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B., & Vandenberghe, L
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