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Several studies have shown that exogenous melatonin can improve memory loss and hippocampal ferroptosis resulting from acute sleep deprivation by interacting with the MT2 receptor to trigger NRF2 signaling
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That area is still developing, and findings vary across medications, populations, and study designs, so it is best treated as an emerging part of the picture rather than a settled explanation
S.TateM.ZhaoY.LockhartS.CalderwoodD.et al (2015)
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