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01 Increases intracellular NAD+ approximately 02 Activates SIRT1 longevity pathway 03 Reduces adipocyte size by Anti-Aging & Longevity 5-Amino-1MQ is a small molecule inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme upregulated in obesity and aging
NAD + is also an essential cofactor for non-redox NAD + -dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases
PU was supported by a grant from the Strategic Research Area Epidemiology programme and a Faculty Funded Career Position at Karolinska Institutet
2010;91(5):1461S-1467S
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