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The Lancet, 397 (10278), 971984
In addition, trials on human and mice showed GLP-1 receptor agonists benefits in heart failure, endothelial lining and,myocardial ischemia.First, heart failure clinical trials on human showed at New York Heart Association involved diabetic patients with stage 3-4 heart failure better response with Glp-1 continuous infusion over 12 weeks duration in the form of better left ventricular ejection fraction and 6 minute walk over 48 hours trial of GLP-1 infusion in nondiabetic patients with stage 2-3 heart failure
By extending and amplifying the GLP-1 signal, semaglutide helps slow gastric emptying, reduce appetite, and improve insulin response
Although glucose-lowering medications may reduce dementia risk through glycemic control, these medications may confer differential benefits to the brain due to activities unique to their different mechanisms of action
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