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Logging symptoms as they happen helps put nausea, fatigue or appetite changes into context, especially during titration, when doses are being adjusted

The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease

Tirzepatide spans 2.5 mg to 15 mg (a 6x range)

Reductions in body weight were significantly greater with the LY3298176 1.5 mg, 4.5 mg and 10 mg doses versus placebo in MAD HS (LSM difference [95% CI]: -1.75 kg [-3.38, -0.12], -5.09 kg [-6.72, -3.46] and -4.61 kg [-6.21, -3.01], respectively) and doses of 10 mg and 15 mg had a relevant effect in T2DM patients (LSM difference [95% CI]: -2.62 kg [-3.79, -1.45] and -2.07 kg [-3.25, -0.88], respectively