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Based on data from Phase 2 clinical trials including the pivotal randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) the most frequently reported sensations and side effects with retatrutide are largely gastrointestinal (GI) in nature
FarahWAbusalihMFHasanBLeesEHFletiFElkhatibWYet al
The SELECT trial addressed this gap by enrolling individuals with overweight or obesity and established cardiovascular disease but without diabetes, demonstrating a 20% reduction in MACE with semaglutide
They tend to be dose-dependent and reversible
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