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Given that glutathione is a tripeptide composed of glutamate, glycine, and cysteine, glutamine-derived glutamate and cysteine need to be ligated by glutamate-cysteine ligase (GCL), which itself comprises two separately encoded proteins: a catalytic subunit (GCLC) and a modifier subunit (GCLM) 53,54
Although these are ideal sources of glutathione, they are largely produced in the human body from glutamate, glycine, and cysteine amino acids, which are easily available from protein-rich foods