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Lipodystrophy and nodule formation Subcutaneous nodules can form after GLP-1 injections, particularly with longer-acting formulations
Rybelsus suits patients who want the metabolic benefits of semaglutide but are unwilling or unable to self-inject a common concern among newly diagnosed patients and older adults, and a reason some skip the injection debate altogether
Increased Hunger: Since it works on the ghrelin (hunger hormone) pathway, some patients feel an urge to eat after dosing
GLP-1 receptor agonists have shown consistent benefit in PCOS: a 2022 meta-analysis in Human Reproduction Update (N=10 trials, 484 women) found that GLP-1 agonist therapy reduced fasting insulin by 1.98 mIU/L, total testosterone by 0.19 nmol/L, and improved menstrual regularity in 55% of participants [10]
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