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"In cases where glutathione demands are high, or there are genetics inhibit glutathione production, glutathione supplementation is often very effective." Taking glutathione itself is problematic because it is a peptide, and peptides break down in the digestive system

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Although there have been mixed results with regard to the amount of incretin secretion, a meta-analysis showed that the secretion of GLP-1 and GIP is not reduced in patients with type 2 diabetes compared to their counterparts without diabetes [18,19]

Kenchaiah S, Evans JC, Levy D et al (2002) Obesity and the risk of heart failure