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It competitively binds p53, displacing endogenous FOXO4 in senescent cells (Baar et al., 2017) 24-72 hours: Freed p53 translocates to mitochondria in senescent cells, triggering the intrinsic apoptotic cascade

Orforglipron treatment was also associated with slower gastric emptying time and short-term weight loss, all of which are consistent with drug class effects , with up to 5.4 kg loss over 4 weeks in higher-dose cohorts

It also helps your body detoxify the liver and promote fat metabolism