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Secondary efficacy measures included changes from baseline in: fast plasma glucose (FPG), postprandial plasma glucose (PPG), area under the curve, insulin, C-peptide, glucagon, insulin/proinsulin ratio, body measurements, and fasting lipid profiles

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The mechanotherapeutic agent ketotifen has been shown to reprogram the TME by reducing tumor stiffness and increasing perfusion, thereby enhancing the delivery and efficacy of nanomedicine-based chemo-immunotherapy (61)