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R Substrates glucuronidated by UGTs include: Acetaminophen (Tylenol) Bilirubin (heme degradation product) Estrogens (estradiol, estrone, estriol) Morphine and opioids NSAIDs (ibuprofen, naproxen) Thyroid hormones (T3, T4) There are four UGT families: UGT1A, UGT2A, UGT2B, and UGT3A
ROS generation occurs via multiple metabolic pathways that are tightly controlled by oxidant and antioxidant signaling and plays an important role in modulating inflammation during viral infections 21,22
Short-acting GLP-1 analogs often result in fluctuating plasma concentrations, contributing to side effects and inconsistent therapeutic outcomes
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