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7.4.4 Next-generation agonists The development of dual GLP-1/GIP receptor agonists (e.g., tirzepatide) and novel blood-brain barrier-penetrant formulations may offer superior neuroprotective efficacy by more potently engaging central receptors or providing a broader spectrum of action (Ghaleb et al., 2025)
These correlations remained significant after controlling for medication use (Supplementary Methods S2 and Supplementary Results S2)
Endocrine Practice , 27(3), 220225
These changes can impact self-esteem, social interactions, and overall quality of life, particularly for those who experience dramatic facial and body transformations after using semaglutide
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