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GLP-1 medications are FDA-approved for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27-29.9) with at least one weight-related comorbidity
Behav Brain Res 356:271278
Treatment typically involves thyroid hormone replacement with levothyroxine to normalize thyroid function, alongside interventions targeting glycemic control and weight management
There is also some evidence that GLP-1 receptor agonists can be used alongside metformin safely, although long-term data is still evolving
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