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1,2 The first-in-class agent targets the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptors, offering a unique metabolic profile that separates it from currently available dual-agonists, such as tirzepatide (Zepbound

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Any unexpected symptom that develops after initiating the combined protocol should be evaluated in the context of potential compound interactions

In second protocol, feeding experiments were started at 19:30 in male mice which had been deprived of food for 3 h (16:3019:30) with free access to water