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Pharmacol Rev 2016;68:4975.PubMed 93

McFadden, C

"And the happy accident involved a rat called the Brattleboro rat." Brattleboro rats are laboratory rodents with a genetic mutation that makes them thirsty nearly all the time

This early data signaled a powerful synergy: PDE5is improve the vascular response while PT-141 boosts central arousal signals, together yielding a stronger and longer-lasting erection