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Increasing the dosage quickly or starting retatrutide at high doses can result in serious side effects
Other potential side effects can include: Diarrhea Constipation Abdominal (stomach) pain Headache Fatigue Dyspepsia (indigestion) Dizziness Abdominal distension Eructation or belching Hypoglycemia (low blood sugar) in patients with type 2 diabetes Flatulence Gastroenteritis (an intestinal infection) Gastroesophageal reflux disease (a type of digestive disorder)
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In August 2025, Wegovy received accelerated approval for the treatment of adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver
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