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Design, Setting, and Participants In a retrospective matched cohort study using data from a centralised data registry of patients evaluated by neuro-ophthalmologists at 1 academic institution from December 1, 2017, through November 30, 2023, a search for International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code H47.01 (ischaemic optic neuropathy) and text search yielded 16 827 patients with no history of NAION
In this six-month prospective cohort study, 200 adults ages 18 to 65 with a BMI of 25 kg/m or higher (classified as overweight or obese) were enrolled and prescribed either the GLP-1 receptor agonist semaglutide or the dual GLP-1/GIP agonist tirzepatide
Notably, in comparative assays measuring neurotrophic activity, Dihexa exhibited potency seven orders of magnitude greater than brain-derived neurotrophic factor (BDNF) in promoting new neuronal connections
participants who developed migraine and those initially diagnosed with migraine both had lower levels compared to controls
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