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10.1016/j.ijpharm.2018.07.012 257
ATP generated through glycolysis and mitochondrial respiration provides the key signal for closure of ATP-sensitive K + channels, subsequently causing membrane depolarization and activation of voltage-dependent Ca 2+ channels (VDCCs), Ca 2+ influx and exocytosis of insulin vesicles 2
Changes in T cells and associated inflammation in adipose tissue during aging CD8 + T cells are critical for adipose inflammation and begin accumulating in the vWAT of middle-aged mice, and particularly in female mice [11]
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