glp 1 gene GLP-1 The Multifaceted Nature of GLP-1:

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Classically, three metabolic alterations have been identified that contribute to the development of T2DM: 1) insulin resistance, 2) an eventual decrease in insulin secretion from pancreatic beta cells, and 3) an excess production of glucose from the liver

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GLP1/E, at very low doses, is sufficient to ameliorate PCOS-associated metabolic alterations Since GLP1/E was superior to any other compound in terms of improvement of metabolic traits, we next assessed the metabolic efficacy of very low doses of this multi-agonist in our metabolically dysregulated PCOS model