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Interleukin 1 receptor-associated kinase 2 (IRAK2), which is highly expressed in PC, promotes the expressions of GLUT1, phosphoglucose isomerase (GPI1), and PDK1 by activating the immune-related pathway (NF-B), thereby increasing glucose consumption and lactate production in cancer cells, providing bioenergetic and metabolic requirements for their survival and proliferation (251)

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Two investigators (HW and TG) independently performed the data extraction from each publication using a standardized form: publication data, baseline characteristics of the study population (sample size, sex, age, body mass index (BMI), body weight, abdominal circumference, waist-to-hip ratio, visceral adipose tissue (measured by computed tomography, magnetic resonance imaging, or dual-emission X-ray absorptiometry)), duration of follow-up, weight change during treatment and after treatment discontinuation, description of the weight management group and control group