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Extracellular administration of glutamate to PC12 cells altered the morphological characteristics of the cells, rendering them devoid of neuronal phenotype and reducing cell viability, which mimicked the atrophy of hippocampus and the decline of neurons in patients with depression ( Our results indicated that ZZCD exerted antidepressant effects through anti-cytotoxicity, anti-oxidation, and anti-apoptosis
The popularity of new GLP-1 drugs for weight loss is giving rise to a secondary market with large revenue potential, and companies are vying for a piece of the action
Importantly, Ebselen mimicked the activity of all selenium-dependent mammal GPXs and affected the redox state
These agents, comprising GLP-1 combined molecules with glucagon or other hormones, have been investigated in preclinical studies for NAFLD treatment
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