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The frequency of NAION in the analyses ranged from 0.07% to 0.24%

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Key features of this combination include: Two complementary mechanisms of glucose reduction Significant HbA1c reduction potential Additional benefits beyond glycaemic control Reduced risk of hypoglycaemia compared to insulin-based regimens (though caution is needed if combined with insulin or sulphonylureas, which may require dose reduction) How GLP-1 Receptor Agonists and SGLT2 Inhibitors Work Together Understanding the distinct pharmacological mechanisms of these two drug classes helps explain why their combination can be effective

Pharmacodynamic interactions occur when drugs influence each others effects directly, either by enhancing or diminishing them