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GLP-1 nausea typically feels like mild queasiness, stomach unease, or a vague sense that you might vomit, though actual vomiting occurs in fewer than 5% of patients during the first month

These results were replicated by an immuno-EM approach in primary mouse islets transduced with a SNAP/FLAG-hGLP-1R-expressing adenovirus, by labelling cell surface SNAP/FLAG-hGLP-1R in intact living islets with membrane-impermeable SNAP-biotin plus streptavidin conjugated to 5-nm gold particles prior to exendin-4 stimulation and TEM processing

Kushner RF

This means the first 20 weeks are the adjustment period, and anything that shows up after that is increasingly rare