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At the higher doses, results were very consistent: All participants lost at least 5% of their body weight Around 3 in 4 lost 15% or more With placebo, only around 1 in 4 lost 5% or more Phase 3 update (TRIUMPH-4, 68 weeks, topline results) In December 2025 , Eli Lilly shared early (topline) results from a larger phase 3 study (TRIUMPH-4)

Potts JE, Gray LJ, Brady EM, et al

Such a redox environment may provide a basis for ROS-dependent signaling pathways to subsequently drive progressive phenotypes such as proliferation, survival, and angiogenesis ( Figure 2 Within the tumor microenvironment, hormonal signaling serves as a critical upstream trigger that drives HGSOC progression through ROS-dependent pathways

J Obes Metab Syndr 32:2545