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The main mechanism of drug induced liver injury is due to the toxicity of the drug itself and the immune reaction, most of the drugs are transformed by hepatocytes, and normal medication will not cause liver injury, but after overdose, a large number of drugs are transformed into water-soluble metabolites by hepatocytes, and the generation of these substances will greatly consume the glutathione in the hepatocytes, resulting in hepatocellular necrosis, and the exogenous glutathione can reduce the toxicity of the drug and the immune reaction, which will cause the liver cell necrosis
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Nonenzymatic, self-elimination degradation mechanism of glutathione
M., Schnackenberg, J., Raote, S., Srivastava, S., Negi, P., & Caston, E
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