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By using different medications that target these various factors, dermatologists can often achieve better and more comprehensive results than by using a single treatment alone
Serious adverse events are rare but can happen
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HFD inhibits the transcription of key antioxidant genes by triggering NRF2 translocation into obese mouse Tregs nucleus, causing a rapid decline in HO-1 expression in Tregs, leading to enhanced oxidative stress and possible ferroptosis, and causing an intensification of obesity and inflammatory responses (156) ( Figure 3 )
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![Biochemical Pathway of Pheomelanin and Eumelanin Synthesis [31–35]](https://www.researchgate.net/publication/384768350/figure/fig1/AS:11431281286228337@1729907538195/Biochemical-Pathway-of-Pheomelanin-and-Eumelanin-Synthesis-31-35-Abbreviations-DHI.png)
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