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Li JR, Cao J, Wei J, Geng W

Source: Jastreboff AM et al., NEJM 2023, supplementary methods

Many users report minimal discomfort, and the injections are typically once a week, making it manageable even for those with a fear of needles

When the skin captures UV radiation, keratinocytes produce -MSH (alpha-melanocyte stimulating hormone), a peptide hormone that binds to melanocytes and stimulates them to produce melanin , a pigment that absorbs UV and protects DNA from damage