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In the case of GSAO, a reversible renal toxicity described in preclinical studies at the maximal tolerated dose was not observed in human during clinical Phase I (Horsley et al., 2013)

Abnormal iron metabolism Iron is a crucial trace element for the human body, and its deficiency can result in anemia and abnormalities in iron-dependent enzymes

Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine

REWIND differed by enrolling a lower-risk population: 9901 patients, two-thirds without prior cardiovascular events, randomized to dulaglutide 1.5 mg weekly versus placebo for a median of 5.4 years