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Along with a significant pool of preclinical data on the effect of GLP-1RAs (including exendin-4) on PD models in experimental animals, showing a decrease in the loss of dopaminergic neurons and accumulation of -synuclein in the brain, a decrease in mitochondrial dysfunction and expression of pro-inflammatory mediators such as tumor necrosis factor (TNF)- and interleukin IL-1 [61], promising data from clinical studies on the use of GLP-1RAs in PD have been obtained [62]

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Debe evitar la semaglutida si tiene antecedentes de pancreatitis, problemas de vescula biliar, enfermedad renal, tumores tiroideos (o antecedentes familiares de ellos), retinopata diabtica o ciertos trastornos digestivos

The benzyl alcohol preservative in bacteriostatic water slows microbial growth but does not stop peptide degradation