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Epitalons appeal lies in its unusually broad mechanistic reach: it can activate telomerase and support telomere maintenance in human cells [12,13,14, 15], modulate gene expression epigenetically by influencing chromatin accessibility and promoter interactions [4], enhance tissue repair in disease contexts such as diabetic retinopathy by reducing oxidative stress and EMT while improving wound healing in retinal cells [16], bolster redox homeostasis by upregulating endogenous antioxidant defenses and lowering DNA-damage markers [1], rebalance immune tone via IL-2 upregulation [17] and shifts in CD4+/CD8+ profiles [18], and even reset circadian biology by tuning core clock genes and melatonin dynamics [19, 20]
Moreover, in a prospective study, reduced glutathione administered alongside blood purification therapy significantly decreased endotoxin levels, inflammatory mediators, and hepatic injury in septic shock patients (Liu and Meng, 2024)
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