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54 In contrast, IR and compensatory hyperinsulinemia cause abnormal activation of ovarian primordial follicles, increasing the sensitivity of pre-antral follicles to follicle-stimulating hormone (FSH), leading to excessive follicle recruitment and ultimately resulting in polycystic ovary-like changes
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Vairetti M, Di Pasqua LG, Cagna M, Richelmi P, Ferrigno A, Berardo C
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