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The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini

These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione

This means the body burns fewer calories at rest and generates less heat