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Once put into the body, whether as an injection or orally, GLP-1 antagonists mimic the actions of a hormone called glucagon-like peptide 1 (GLP-1)

Orforglipron represents the next evolution in this space as a highly effective, non-peptide oral GLP-1 receptor agonist

But before assuming that a GLP-1 medication has stopped working, clinicians will typically consider how the patient is using the drug, such as whether its being taken properly, with little to no missed doses, and whether it is being stored properly

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