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Treatment with tirzepatide in adults with pre-diabetes and obesity or overweight resulted in sustained weight loss, and nearly 99% remained diabetes-free at 176 weeks | Eli Lilly and Company

NSAIDs can reduce kidney function further, making concurrent use slightly riskier for individuals with renal history

Additionally, SCFAs reinforce intestinal barrier integrity, mitigating endotoxemia-induced systemic inflammationa key driver of insulin resistance (Liu et al., 2021