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The heart-rate increase means it might not be the right choice for people with significant heart-rhythm conditions, but thats a clinical judgement to make once full data is available

By incorporating specific evaluation metrics, such as drug-likeness and synthetic accessibility, the generated linkers show favorable theoretical drug-like properties and synthetic accessibility, though their actual efficacy, safety, and stability require further experimental evaluation

Your risk is also higher if you have a history of diabetic retinopathy

Continuous long-term use is reserved for specific clinical situations under careful monitoring