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Modern whole-body cryotherapy emerged in Japan during the 1970s when Professor Toshiro Yamauchi observed that rheumatoid arthritis patients returning from winter mountain holidays showed improved symptoms

Published human evidence includes topical applications over defined periods, diabetic-ulcer wound protocols, and a registered topical acute-wound trial, while there is no FDA-approved injectable GHK-Cu label that establishes a standard dose [2], [3], [7], [8]

The question is whether topical delivery is enough

The knockout findings indicate a more complex relationship involving chronic receptor-associated adaptation and beta-3-independent acute effects