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The sNDA was based on results from the Phase 3, double-blind, parallel-group, placebo-controlled cardiovascular outcomes trial, SOUL. The trial reported a 14% reduction in the risk of MACE compared to placebo when added to standard of care in patients with T2DM and established CVD and/or CKD

The compounded semaglutide guide explains the differences between brand-name and compounded versions

These gastrointestinal symptoms are typically most pronounced during dose escalation and often diminish over time as patients develop tolerance

Nodes within the comorbidity network that were disconnected (i.e., lacking edges or connections to other nodes) were not initially assigned a score, as centrality metrics depend on network connectivity