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The first 23 weeks are really the adjustment phase

Trends Biotechnol (2002) 20:1238

Across all targets, future studies should emphasise quantitative sequence-structure-selectivity relationships, including how donor sets, geometry constraints, and microenvironment tuning govern discrimination between closely related ions and oxidation states, with the rapid progress in elucidating REE-protein binding over the last decade providing a useful template for this approach

Research from the STEP trials shows that gastrointestinal side effects peak during dose escalation periods and then gradually subside over 1 to 2 weeks at the new dose