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Research on GLP-1 discontinuation shows that most patients regain a significant portion of lost weight after stopping the medication, which means many patients need some form of ongoing treatment, often at a lower dose, to maintain results
There are multiple common polymorphisms(genetic differences) that can lead to this outcome
As well, a new Canadian pharmaceutical company called Vimy Pharma, founded by two former Novo Nordisk Canada executives, has said it plans to launch a generic semaglutide, too
100102 In addition, inflammatory cytokines are reportedly involved in CYP gene expression, with the reduced cytokine levels-mediated by GLP-1 RA administration may alter CYP gene expression, potentially leading to changes in the pharmacokinetics of co-administered drugs (Figure 3)
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