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Diarrhea and constipation may alternate
To understand the metabolic changes induced by dual inhibition, we comprehensively tested human and murine PDAC cell lines, endogenous tumor models, and patient-derived organoids, which are representative of the full spectrum of PDAC molecular subtypes
Oral supplementation often requires significantly larger daily doses to reach comparable levels in the body
Increases of 2.5mg occur no more frequently than every four weeks
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