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Unraveling the Connection, the answer lies heavily in this shared pathophysiology of broken redox balance

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(PubMed) Huang TS, Shyu YC, Chen HY, et al

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Subeffective dosages of metformin combined with L-NAME and 7-NI reduced CQ-induced scratching behavior, whereas L-arginine reversed the effect, indicating the involvement of the NO pathway in pruritus [14, 15]

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