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Orforglipron (Orfoglip), approved in 2025, is the newest oral GLP-1 agonist

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Step two: adding injectable therapy When metformin alone (or metformin plus other oral agents) fails to achieve blood sugar targets, the next decision is whether to add a GLP-1 agonist or insulin

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54 Estimated Glomerular Filtration Rate (eGFR) The estimated glomerular filtration rate (eGFR) test measures how well the kidneys are filtering and excreting certain substances in the blood (eg, creatinine or cystatin C)

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