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It is the single most alarming safety signal on the label, and it is the #1 reason patients hesitate to start therapy

Orlistat is generally avoided or used with great caution in people with a history of kidney stones, hyperoxaluria, or significant CKD, due to the oxalate-related risks described above

It may also help prevent side effects that sometimes happen when medication is stopped too quickly, such as increased hunger or digestive problems

However, it offers some caffeine (about half that of standard coffee), plus six grams of protein and functional ingredients like L-theanine to improve alertness without a cortisol spike or energy crash