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Together, our findings uncover a TRIM37TRIM28AP2 regulatory complex that safeguards germ cell fate by preventing the activation of somatic transcriptional programs during PGC migration

This dose should be maintained for at least four weeks to assess tolerance and initial therapeutic response before considering further dose escalation

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This potential restoration of p53s function by the FOXO4-DRI peptide might enable it to trigger the programmed cell death of senescent cells, essentially clearing out cells that might otherwise contribute to the decline in tissue function seen in aged cell cultures