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To normalize read counts, RPKM (Reads Per Kilobase of transcript per Million mapped reads) values were calculated in 100-bp bins using bamCoverage from deepTools (v3.5.1)

Two robust regression LME models (package(nlme)(Pinheiro et al., 2023)) were estimated for each brain region to investigate the relationship between metabolite (GSH or GABA+) levels and diagnosis group, age, and sex, accounting for the random intercept of each participant

In recent years, pharmaceutical companies have released new therapies that mimic the natural hormone glucagon-like peptide-1 (GLP-1)