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The involvement of DPP-4 in metabolism of endogenous SDF-1 is compatible with the finding that the truncated metabolite, SDF-1 3-67, was present in wild-type mice, but not in animals lacking DPP-4 (62), with this observation being extended in subsequent studies in mice and Rhesus monkeys (63) and in patients with T2DM (64) showing that levels of SDF-1 3-67 were reduced while those of the intact 1-67 form increased concomitantly when DPP-4 activity was inhibited

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Of note, although hospitalization for HF alone was an exploratory end point, HARMONY is the only CVOT to show lower risk of HF hospitalization with GLP1 RAs versus placebo (hazard ratio [HR], 0.71 [95% CI, 0.530.94])

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