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Mathieu, R

Ewing et al.21 found many macrophages with rich pigment deposition on the mucosal lamina propria of the colon, the colonic submucosa and the submucosal lymphatic vessels through hematoxylin and eosin (HE) staining, which could also be discovered in the colonic mucosa and lymph nodes by periodic acid-Schiff staining (PAS), melanin staining, Fite staining and Congo red staining.22 Gomori iron staining is negative in the colonic mucosa and lymph nodes, as is the immunohistochemistry results for S100, keratin and HMB-45

If B12 levels are already within a normal range, additional B12 may not lead to noticeable changes in energy or performance

Makani et al., 2011