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Systematic exploration of thioredoxin target proteins in plant mitochondria

Basal ROS levels ( d ), lipid ROS levels ( e ), and relative MDA levels ( f ) were measured

These findings indicate that GpoA, TpxD, and AhpD constitute a robust H 2 O 2 detoxification system that depends on extracellular GSH uptake

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5