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In animal models, these compounds alleviated both acute pain and chronic pain induced by nerve injury
Clinical EPP patients on afamelanotide implants do experience increased pigmentation and improved tolerance to sunlight, but they do not typically become deeply bronzed in the way Melanotan II users often do
Overall, our results suggest that DA functions uniquely at 2A -adrenergic receptors as a G protein-biased agonist by selectively directing intracellular signaling towards G protein-mediated transduction pathways
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